LB-S&T-09 IMIDAFENACIN-IMMUNOTOXIC PROPERTIES STUDY

Total Positivity Properties of LB-splines

A basic property of both polynomial and more general Tchebycheffian splines is that the associated B-spline collocation matrix has certain total positivity properties, and it is nonsingular if and only if well-known interlacing conditions hold. Using a technique from a recent paper of Mørken, we extend these results to L-splines. §

Purification of Buchnericin LB Produced by Lactobacillus buchneri LB

Buchnericin LB produced by Lactobacillus buchneri LB was purified to homogeneity by a rapid and simple three-step purification procedure including freeze drying, silicic acid adsorption/desorption and cation-exchange chromatography. After the silicic acid and cation-exchange chromatography steps, the activity of buchnericin LB was recovered by 85 and 25%, and its purity increased about 111 and ...

Immunotoxic Effects of Lambda-cyhalothrin in Rabbits

The effect of Lambda-cyhalothrin on the immune response was studied in rabbits exposed to the insecticide via food at concentrations of 1373.23, 686.76 or 343.38 ppm (equivalent to 1/10, 1/20 and 1/40 oral LD50, respectively) for 8 weeks. The humoral immune response was measured by determination of the antibody titre against sheep red blood cells (SRBC), a T cell dependent antigen. Moreover, th...

Functional assays are mandatory for a correct prediction of immunotoxic properties of compounds in vitro.

An increasing aim in safety assessment of chemicals and drugs is to reduce, refine and replace animal testing, especially in the context of the new system for the registration, evaluation and authorisation of chemicals (REACH). Regarding immunosuppression, most methods are based on mitogen stimulation assays. To our knowledge the in vitro antibody response (Mishell-Dutton culture) has never bee...

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